Posted at 05:54 PM in Politics | Permalink | Comments (0) | TrackBack (0)
Technorati Tags: California politics, Fascism, Hitler, Jerry Brown, Meg Whitman
By Carlos Miller
In front of a cable/satellite news team with cameras rolling, a
Miami-Dade Metrorail security guard ripped my video camera from my hand,
knocking it to the ground, before pocketing it and refusing to return
it.
The guard then began pushing me aggressively after I had pulled out my iPhone to continue recording – all while telling me to stop pushing him.
He then struck my hand again in an attempt to snatch the iPhone.
I struck him back, busting his lip.
It was the second time within a month that I had a confrontation with security guards over videography at the Douglas Road Metrorail Station. The first time resulted in a captain from 50 State, the security company that contracts with Miami-Dade County, to “permanently ban” me from the Metrorail.
However, I was never served an official notice. And I did not commit a crime to merit being banned from a public-funded facility in the first place.
After Thursday’s confrontation, paramedics were called to treat the security guard. Cops were called to decide whether I needed to be arrested on battery charges. Or trespassing charges.
Or illegal videography charges, which do not exist but might as well considering how they reacted to me Thursday morning.
The entire incident will be broadcast in an upcoming documentary segment on HDNet TV World Report, the network owned by Dallas Mavericks owner Mark Cuban – the same network that hired Dan Rather when CBS terminated his contracted after 44 years.
The news crew was in town to interview me about Photography is Not a Crime for an in-depth segment on photographers’ rights that will be aired in about three weeks.
Before the incident, I was talking to correspondent Greg Dobbs – who has one hell of a bio – about how I was permanently banned from the Metrorail last month with Stretch Ledford, who is in Europe or else he would have been with us.
We walked through the parking lot of the Douglas Road Metrorail Station and purchased tickets. Dobbs and I then walked inside through the turnstile with me holding up my Canon TX1. The rest of the news crew remained outside.
Within seconds, I was accosted by the female security guard as well as the male security guard wearing a black beret and a single latex glove who knocked the camera from my hand.
I demanded my camera but he refused to give it back.
Then I remembered I had my iPhone, so I started shooting video with that, which prompted the female security to get in my face.
She even lifted her fist up a couple of times as if she was going to strike me.
I kept trying to walk away from her while holding up my camera, which is why the video is so shaky.
The male guard then came after me and I also tried walking away from him while videotaping.
But when he struck me, I struck back instinctively.
He then pulled out a metal baton and came after me with it.
I stepped outside the station and he sat down to tend to his lip.
Miami-Dade detectives who arrived on the scene were considering charging me with battery until they saw the footage shot by the news crew.
After two hours of talking to cops, my camera was returned to me, minus a battery that somehow got lost.
The initial footage of the first assault was not on the memory card, so I suspected they had deleted it. But then when I tried to recover it with recovery software after I had gotten home, I could not find it either. So maybe I had just forgot to hit record.
Thankfully, the news crew did not do the same.
I also realize that I must learn how to hold the iPhone horizontally if I’m going to shoot video, which I rarely do because I always have my TX1 on me. But it did serve as a nice back-up.
After the morning excitement, we had lunch and went to my place where
we continued the interview in front of my computer. They then drove up
to West
Palm Beach to interview Tasha Ford about the story I broke on PINAC
last year.
And later in the week, they will fly up to Washington DC to continue interviewing people engaged in the struggle for photographers’ rights.
Posted at 05:43 PM in Politics, Technology | Permalink | Comments (0) | TrackBack (0)
Technorati Tags: culture, first amendment, free speech, politics, society
OK, the quote in my headline isn't an actual quote, so sue me! Meg Whitman's ads are such incredible distortions, a new low in political advertising. Factcheck.org and media outlets throughout California have pointed out the falsehoods in her advertising, yet, she stands steadfast behind every single lie she is spending millions of dollars to broadcast. Watch this:
If this pisses you off, and you want to do something about it, click here: Jerry Brown.
Posted at 07:28 PM in Politics | Permalink | Comments (0) | TrackBack (0)
Technorati Tags: 2010 campaign, California, Jerry Brown, lies, Meg Whitman, politics
Just in case you think Apple rules the universe because they sell a ton of little cute gadget thingies, think again. When it comes to REAL Computers, Microsoft is still in the driver's seat.
Posted at 03:28 PM in Steve Jobs, Technology, Web/Tech | Permalink | Comments (0) | TrackBack (0)
Technorati Tags: Apple, business, computers, Microsoft, PCs, technology
Posted at 09:58 AM in Genetics, Science | Permalink | Comments (0) | TrackBack (0)
Technorati Tags: DNA, education, genetics, genome, science, technology
Coming out in October, The Social Network, a movie about the founding of Facebook is going to be a huge hit. I'm reading the book upon which it is based, "The Accidental Billionaires" by Ben Merzrich and enjoying it immensely.
It's not exactly a history book, rather a blend of fiction and fact, which is probably why it is so much fun to read. As Merzich confesses in the Introduction, "I do employ the technique of re-created dialogue."
Reportedly, Facebook founder Mark Zuckerberg and the members of his inner circle already hate the movie even though they haven't seen it. According to Kara Swisher of All Things Digital, "Zuck" is dreading its release because of "inaccuracies" in the book it is based on.
Can't say I blame him, but what the hell, as the trailer says, "You don't get to 500 Million Friends without making a few Enemies."
Note to author Merzich: ALL BILLIONAIRES ARE ACCIDENTAL.
Posted at 03:33 PM in Entertainment, Film, Technology | Permalink | Comments (0) | TrackBack (0)
Technorati Tags: billionaires, Facebook, property theft, technology, zuckerberg
In 1974, explaining why he was cutting a lot of programs and slashing budgets as Governor of California, Jerry Brown said, "it's not because I'm conservative, it's because I'm cheap."
Meg Whitman should watch these videos. Jerry Brown was never the free-spending liberal she portrays in her completely misleading and inaccurate advertising. He was noted for his "small is beautiful" philosophy, fiscal conservatism, and entrepreneurial imagination. When local governments were going broke because of Proposition 13, Jerry bailed them out using the accumulated surplus he had build up at the state level.
His record as Governor of California is outstanding. There's never been a governor like him and we could use another dose.
There is no "embedded code" for these YouTube videos, but here's the link.
Posted at 03:30 PM in Current Affairs | Permalink | Comments (0) | TrackBack (0)
Technorati Tags: California, governor, Jerry Brown, Meg Whitman, politics
Robots have been with us for several decades, but lately robot technology has accelerated to the point where sooner than you might think there will be human-like robots among us. This remarkable video from Honda will give you a good idea about where we are headed:
Posted at 10:17 AM in Science, Technology | Permalink | Comments (0) | TrackBack (0)
Technorati Tags: automation, future, robots, singularity, technology
To understand why Andrews should be taken seriously, you first need to know a few basics about telomeres. Once considered nothing more than a relatively long strand of "junk" DNA at both ends of every chromosome in the human body, we now know telomeres are vitally important. When chromosomes divide and multiply, instead of losing DNA that matters, chromosomes only lose some of the telomere's DNA.
With each and every replication of our DNA, part of the telomere sequence is chopped off. This is how nature protects the DNA in a chromosome. Today, scientists can measure the age of cells by the length of the telomere--the cells in infants have long telomeres, the cells in adults have shorter telomeres. When telomeres become too short (less than 5,000 "base pairs") cells can no longer divide. Then one of two things happens; the cell either enters a state of paralysis called "senescence" or it simple commits suicide (apoptosis) and dies.
What came first, Dr. Andrews, your interest in telomeres or your interest in anti-aging?
I
can remember when I was around 10 years old, my father, who realized I
was very interested in science, said, "when you grown up why don't you
become a doctor and cure aging?" He used to tell me all the time he
doesn't understand why "no one has cured aging yet" and you know, I
automatically thought of aging as a disease. (Bill is pictured here with his dad, Ralph, who is 83)
I became obsessed with this idea of curing aging and all through high school, college, graduate school everyone knew that that was my mission in life. It was only after I got into anti-aging research that I found out the whole idea of aging as a disease is a concept that very few people understand.
You had quite a career going at the biotechnology company, Geron Corporation. You were one of the inventors of the year and you had quite a lot of patents. So why did you leave and start Sierra Sciences?I was afraid I would wake up 20 years from now and nobody did this. I went to Geron because their mission was to find a way to turn on telomerase to expand lifespan. After we cloned the telomerase gene, we did 2 experiments. We put it into normal cells and showed it could stop the aging process but we also took the anti-sense of telomerase and showed it could kill cancer cells, very quickly.
So Geron, even though their name comes from the word "gerontology" chose to go after cancer because the investors realized, and they were correct in this, there was a quicker return on investments doing cancer research.
I was a little stunned by, a little upset about it. I'm very interested in cancer research but it seemed like enough people were already doing cancer research and not enough people focused on aging. So I left and created Sierra Sciences to continue the work on telomere biology and telomerase to control the aging process.
My big fear was, if I didn't, as I said before, I'd wake up 20 years from now and find out that nobody even tried.
What lead you to believe telomeres are the key to all this? Some people say, 'sure, they are biomarkers of aging, but they probably don't cause aging.'As long as I've been interested in aging I've been wondering why would environmental effects cause aging? I'm sure they do play a role in aging but if they were the only thing or the main thing causing aging we would see people in different environments aging at different rates. This told me there is some kind of clock ticking inside of our cells and what was that, what possible clock do we have and what kind of clock could explain why cats have a maximum lifespan very different from humans?
I was baffled by this for many years. I started attending anti-aging conferences, always keeping an eye out for something that could be this clock.
And then, about 15 years ago, I listened to Calvin Harley, the Chief Scientific Officer of Geron Corporation
speak at a conference in Tahoe City at the Granlibakken Resort. He started explaining how telomeres shorten when cells divide and how there was a correlation
between the telomere length and the age of a person.
I found myself sitting there nodding my head, thinking "this is it. This guy has figured it out." Of course, other people working with Cal figured it out too including Nobel Prize winners Elizabeth Blackburn and Carol Greider, but then it was all new to me.
I made an effort to meet Calvin as he was walking off the stage after his talk and simply said to him, "Calvin, I want to work with you. This is what I want to do."
Two weeks later I was working at Geron Corporation on this mission.
Amazing, and you've been at it ever since.
Yes, indeed I have, and to get back to answering your question, why do I believe telomeres are the key to aging. At that time it was the only explanation that I could come up with. I just knew this was it, but of course since then there has been an overwhelming amount of research showing that telomeres play a role in aging. And ever since we lengthened telomeres by putting telomerase into cells, that's been the real coup de grâce. We proved that by lengthening telomeres, we can actually make cells younger.
There is some concern that in lengthening telomeres you might also cause people to get cancer. Or suppose somebody already has cancerous cells, wouldn't you be inducing the telomeres of the cancer cells to grow as well as the normal cells?
That's a very good question. Nobody has shown today whether telomerase increases or decreases the risk of cancer. I think there is overwhelming data showing it is actually going to decrease the risk of cancer. There are still people who believe the opposite, for legitimate reasons, but I think they are getting fewer and fewer.
But you didn't say, "Will telomerase cause cancer," you said, "Will longer telomeres cause cancer," and I don't think most people believe that. I believe if you make telomeres long that will decrease the risk of cancer and just about everything else, everything bad for you.
Short telomeres are bad. Short telomeres will cause cancer, so keeping the telomeres long will prevent that cell from becoming a cancer. It is well known that a cell requires 8-to-10 mutations before it can become a cancer. I believe that most of those mutation are induced by short telomeres. So keeping telomeres long is a way to prevent cancer, and it can also help fight the cancer.
Another thing some people are saying is that moles and polyps increase the risk of cancer. They are precancerous but when you look at the size of a polyp or mole you can estimate it to be approximately 10-to-the-7th cells
(107)
. It takes about 30 cells divisions to make cells this big. So, if you have a single cell that has lost growth control but still is not yet a cancer, the telomeres will get really short because of all the cell division.
The reason moles and polyps are precancerous is because of their short telomeres. By turning on telomerase, you can lengthen those telomeres and therefore decrease the odds that they are going to cause the other mutations that cause cancer. By having a telomerase inducer, moles and polyps can grow and keep their telomeres long.
There are studies that show telomeres in polyps and moles are long but someone as experiences as me in measuring telomere length knows it is very difficult to do this accurately. A lot of time in these papers I believe people really didn't have a good way of measuring telomere length. And the same thing goes true for measuring telomerase activity. Now then if a mole or polyp already has telomerase activity then an inducers is not going to effect that cell in any way.I believe a telomerase inducer will help you fight cancer. If you already have a cancer, taking a telomerase inducer it's is not going to help your cancer cells stay immortal, but it will boost your immune system. When the telomeres in immune cells get really short they loose the ability to fight. But if you take a telomerase inducer, you can keep the telomeres in your immune cells long and maintain the ability of your immune cells to fight the cancer.
The immune sytem is actually pretty effective at
fighting cancers. This is one of the reasons cancers are a lot more
prevalent in the elderly because older people have shorter telomeres in
their immune cells.
(editor's note: New study published in JAMA validates some of the points Dr. Andrews makes above concerning telomere length and cancer. Click here to see the JAMA article.)
Years ago people were telling us it is impossible to find a telomerase inducer and I think that is part of the reason we have no competition. Nobody else has decided to make the effort to look for a telomerase inducer.
We found our first drug to induce telomerses 2 1/2 years ago and we sent it to all the people who had told us it was impossible and had them test it. Sure enough, they all came back and said "Wow, it works!" They didn't understand why it works but it does work.
Since then we have gotten up to 39 different families of drugs or chemicals that induce telomerase and we're up to about 12% of what we need, or think we need, to make human cells immortal. And actually that is pretty high because we think it won't be too much harder, using structure activity material relationship activities and learning the mechanisms of action of these drugs, to figure out ways to make these chemicals more potent. But at that point we then have to go through FDA trials and that is going to require up to 12 years to get something to the market.
We think we can get this into the pet market earlier.
Oh really, amazing.
Our colleagues at the University of Texas at Southwestern and the University of Edinburgh have found cats, dogs and horses all age by telomere shortening, even though mice don't and other rodents don't. We think we can sell our telomerase inducers to the cat, dog and horse markets. Many of the owners will buy a lot of it to extend the lifespan and the healthspan of their pets. Unfortunately the people who love their mice and their rabbits won't benefit because these animals age by different mechanisms.
We also see earlier opportunities in the stem
cell market. Recently, we coauthored a paper with Mike West at BioTime Corporation showing that induced pluripotent stem cells have
shorter telomeres than you would like. So, let's say you want to take
cells from an elderly person and induce them to become pluripotent stem
cells and then put them back into a person. Well, they are not going be
as effective because the telomeres in older stem cells are short. So, I think a telomerase inducers is
going to be very, very useful for that whole market.
And there's a few other research markets where telomerase inducers will be useful, but even more exciting is the possibility of fighting life threatening diseases, some of which could be FDA fast tracked. For sure, this would include progeria, a disease where kids age very rapidly age and die before they are 20. Our company is very interested in that disease even though we don't see it ever making us any money. I can tell you every employee here would feel great self-satisfaction knowing we'd come up with a way of helping these kids even though there is only 15 in the world at any one time. Helping them to live a normal life would be wonderful.
There's also the immune systems of AIDS patents. When a person first gets infected with the AIDS virus the immune systems puts up a pretty big fight. Ultimately though it is unsuccessfully because of the fact the AIDS virus is pretty much inside the immune cells. So in this effort to fight off the virus the telomeres of the immune cells get really short. This is why back in the early 80's when AIDS was first discovered doctors were surprise to find these AIDS patents had no T cells. It's because the telomeres got short and essentially the immune cells died of old age.So there is a lot more to your efforts than just the single goal of immortality?
The goal is not to just make us older, the goal is to make us healthier. When I'm 140 years old, I want to look and feel like a 24 year old. The goal is not to extend lifespan, the goal is to extend healthspan.
I keep a list of all the different diseases related to telomere shortening and this list has gotten to way over 100 different diseases that humans suffer from that are controlled by telomere length. That includes cardiovascular disease, cancer, which we just discussed, macular degeneration, osteoarthritis, osteoporosis, and some more recent data is showing a big correlation between Alzheimer's disease and telomere length. Keeping telomeres long could prevent Alzheimer's or could stop the progression of Alzheimer's if a person is diagnosed with it.
Even if telomeres didn't have anything to do with lifespan people would live longer because the number one cause of death is heart disease and cancer. If we can decrease that significantly we are going to increase the average lifespan and healthspan of humans.
When you are a centenarian, you obviously plan to be different from today's centenarians. You say you want to run a 7-minute mile when you are 130 years old.
I'm
an ultramarathon runner. I've been running ultramarathons since 1986
and almost all ultramarathon runners have their biography written to a
website, run110.com. If you read my
bio, which has been there unchanged since 1997, it says my ultimate goal is to run the
Western States 100 mile race when I'm 100 years old and I plan on have
my father, who will be 125 at the time, crew for me. (link to Bill's bio)
That was my first bold statement. And yes, my most recent bold statement is I'm going to feel like we succeeded in what we are doing when I run a 7-minute mile when I'm 130 years old or when somebody else does before me.
Is there an existing record for 100-year-olds running the mile or a marathon?
I know there have been 90-year-olds who have run a marathon, but I don't think there is a record for the marathon at 100. But I think it will happen before I get a shot at it because there are number of older athletes doing supper well running ultramarathans and marathons.That's a very tough thing to do. I am very eager to live forever and I have to really exercise a lot of discipline in order to do that. I sacrifice my social life but I feel that what I lose in a social life right now I'm going to make up 10 fold more after I have a cure for aging and figure out a way to extend my lifespan.
I think when you are 130 and can run the mile in 7 minutes, you'll have a lot of friends and fans. Can you imagine? (laughter).
Yes,
I can imagine. As I said, I'm eager to live forever and I know I'm
never going to live forever, I'm going to die early, if I don't keep
fit and stay in shape. There is a lot of supporting data that has come
out in just the last couple years showing that good health, physical
and mental health help keep your telomeres long.
Put differently, being unhealthy both physically and mentally accelerates telomere shortening by creating stress inducing free radicals. Free radicals actually clip DNA telomeres making them shorter and also causing tissue damage thereby inducing cell division to repair that damage. Whenever you induce cell division you get telomere shortening.
Studies have been published in two major publications in the last
year showing endurance athletes have longer
telomeres than people who aren't as athletic or who are
sedentary. Obesity has been shown to affect telomere length and lack of omega-3
fatty acids and vitamin D have been shown to affect telomere length.
Everytime I hear or read about something new I include that in my regimen. I exercise, try not to get obese, and take my omega-3 and vitamin D.
But then on the mental side it has been shown that people who have a lot of mental stress have shorter telomeres. Elizabether Blackburn has published some great papers finding people who are caregivers for Alzheimer's patients have shorter telomeres because they are clearly under a lot of stress. So meditation might be something that can prevent telomere shortening.
Even pessimism, people who are pessimistic have been shown to have shorter telomeres. If you ask a person a question like do you think you will live to be 100 and they say "no" they probably won't because thier telomeres are going to be shorter. But if they answer "yes" the probably will because their telomeres are going to be longer.
So, I try to be very opltimistic, not pessimistic. I try to cause everybody else to have stress, not me.
Do you meditate and if so, how often?
Yeah, I meditate ... I've gone to meditation people and they tell me I already meditate.
From the running?
Well, running and I learned a long, long time ago, maybe when I was back in high school, I just go into a self meditation type mode and it helps a lot. Every time I get on an airplane as soon as I'm sitting in the plane, everything is ready and the plane starts to move, I always fall asleep and I usually sleep through the whole flight.What's more important, diet or exercise?
Clearly exercise. I'm trying to figure out if there is a diet that could keep your cardiovascular system strong without exercise. However, I think you cannot separate one from another because if you ate at Burger King three meals a day and ran 10 miles a day you are still going to get cardiovascular disease and die.Nobody has ever asked me that question. One thing I will mention is antioxidants clearly prevent telomere damage. A lot of fruits, particularly blueberries, contain a lot of antioxidants.
Is there anything else you'd like to include in this inteview?Just that bad things happen when telomeres get short and so, let's keep them long.
Posted at 10:19 AM in Fitness, Healthy Lifestyle, Longevity, Medical Breakthrough, Meditation, nutrition, Supplements | Permalink | Comments (7) | TrackBack (0)
Technorati Tags: antiaging, Bill Andrews, biology, life extension, longevity, science, Sierra Sciences, telomeres
Posted at 11:50 AM in Politics | Permalink | Comments (0) | TrackBack (0)
Technorati Tags: California, Jerry Brown, Meg Whitman, Politics
